Different forms of the APOE gene can either protect against or increase the risk of Alzheimer’s. Lipids associated with these genotypes could be therapeutic targets to prevent or treat the onset of this disease.
The structure of filaments that come together to form amyloid plaques differ depending on whether a person has sporadic or inherited Alzheimer’s disease, or a different degenerative brain condition.
People with Alzheimer’s have more senescent cells in their brains than people without this disease, a new NIA-supported study shows. These neurons have high levels of tau tangles.