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Dose Response Study of Aerobic Exercise in Older Adults

Start: May 2010

End: April 2014

Enrollment: 100

What Is This Study About?

This 26-week study will assess the effects of three doses of moderate-intensity exercise in sedentary older adults who have age-related cognitive changes but no dementia. Aerobic fitness, physical function, and cognition will be assessed at baseline and 26 weeks to examine the dose-response relationships. At 52 weeks, cognition will be reassessed to examine the durability of cognitive changes.

Do I Qualify To Participate in This Study?

Minimum Age: 65 Years

Maximum Age: N/A

Must have:

  • Underactive or sedentary, based on the Telephone Assessment of Physical Activity
  • Community dwelling, with a caregiver willing to accompany the participant to clinic visits; caregiver must visit with the subject more than five times a week
  • Nondemented: Clinical Dementia Rating = 0
  • Adequate seeing and hearing abilities to perform all aspects of the cognitive and functional assessments
  • Stable doses of medications for at least 30 days prior to screening are allowed

Must NOT have:

  • Dementia: Clinical Dementia Rating > 0
  • Current major psychiatric disorder; significant psychiatric symptoms (e.g., hallucinations) that could impair completion of the study
  • Current clinically significant systemic illness or infection likely to result in deterioration of the participant's condition or safety during the study
  • History of clinically evident stroke; myocardial infarction or symptoms of coronary artery disease (e.g., angina) in the last 2 years; uncontrolled hypertension within the last 6 months
  • History of cancer within the last 5 years (except nonmetastatic basal or squamous cell carcinoma)
  • History of drug or alcohol abuse
  • Insulin-dependent diabetes mellitus
  • Significant pain or musculoskeletal disorder that would prohibit participation in an exercise program

If I Qualify, Who Do I Contact?

Contact study personnel listed either under the general study contact or the location nearest you.

Need Help?

Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.

Where Is This Study Located?

Kansas
University of Kansas Medical Center
Kansas City, 66160

Who Sponsors This Study?

Lead: Jeffrey Burns, MD

Source: ClinicalTrials.gov ID: NCT01129115