What Is This Study About?
This study will examine the effects of taking a dietary supplement, magnesium L-threonate (brand name, Magtein), in people with mild to moderate dementia and a magnesium deficiency to see if it will improve memory and/or magnesium deficiency.
Do I Qualify To Participate in This Study?
- Mini-Mental State Examination score of 16-24
- Adequate seeing and hearing ability to allow neuropsychological testing
- More than 12 years of educational achievement or a General Education Development certificate
- Women must be surgically sterile, postmenopausal, or use an acceptable method of birth control
Must NOT have:
- Active heart disease
- Uncontrolled high blood pressure (≥ 140/90 mmHg)
- Renal or hepatic impairment/disease
- Type I diabetes
- Unstable thyroid disease
- Psychiatric disorder requiring hospitalization in the past year
- Drug or alcohol abuse in the past 12 months
- Immune disorder such as HIV/AIDS
- Transient ischemic attacks, carotid bruits, or verified lacunes
- Significant pulmonary disease
- Contraindication for PET scan, including a stroke or heart attack in the past 6 months or inability to lie down for 1 hour
- History of cancer (except localized skin cancer without metastases or in situ cervical cancer) within 5 years prior to screening
- Prohibited medications: medications known to interact with magnesium; antibiotics; vitamins, minerals or dietary/herbal supplements other than the study product until after study completion
- On an unstable dose of medication (defined as fewer than 90 days at the same dose)
- Allergy or sensitivity to any ingredient in the test product
- Pregnant , lactating, or planning to become pregnant during the study period
- Participation in another research study within 30 days prior to the screening visit
Contact study personnel listed either under the general study contact or the location nearest you.
Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.
Where Is This Study Located?
Stanford University School of Medicine, Department of Psychiatry & Behavioral Sciences
Lead: Stanford University
Source: ClinicalTrials.gov ID: NCT02210286