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Find more clinical trials

4 Repeat Tauopathy Neuroimaging Initiative Cycle 2 (4RTNI-2)

Start: January 2016
End: December 2021
Enrollment: 232

What Is This Study About?

This study will identify reliable methods for tracking the progression of corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), and oligosymptomatic/variant progressive supranuclear palsy (o/vPSP) over time. Researchers will conduct a variety of tests, including brain imaging, eye movement, retinal imaging, blood and cerebrospinal fluid samples, and measurements of cognitive function. The results of this study may help the development of treatments for these neurological diseases. The study will also provide information about how brain imaging techniques for diagnosis compare with testing blood, urine, and cerebrospinal fluids.  

Do I Qualify To Participate in This Study?

Minimum Age: 40 Years

Maximum Age: 80 Years

Must have:

  • Diagnosis of CBD, PSP, or o/vPSP
  • Reliable study partner who has frequent contact with participant and can accompany participant to research visits
  • Ability to walk five steps with minimal assistance

Must NOT have:

  • Significant neurological disease other than CBD, PSP, or a variant PSP syndrome
  • Pacemaker, aneurysm clip, artificial heart valve, ear implant, or metal fragments or objects in the eyes, skin, or body

If I Qualify, Who Do I Contact?

Contact study personnel listed either under the general study contact or the location nearest you.

Study Contact
Adam Boxer, MD, Phd
Hilary Heuer, PhD

Need Help?

Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.

Where Is This Study Located?

University of California, San Diego (UCSD)
San Diego, CA 92037
Ileana Rubio
University of California, San Francisco (UCSF)
San Francisco, CA 94158
Stephanie Vento, BS
Johns Hopkins University
Baltimore, MD 21287
Diane Lanham
Harvard University - Massachusetts General Hospital
Charlestown, MA 02129
Samantha Krivensky, BA
Mayo Clinic - Rochester
Rochester, MN 55905
Ruth Kraft
New York
Columbia University
New York, NY 10032
Masood Manoochehri
University of Pennsylvania
Philadelphia, PA 19104
Dahlia Kamel

Who Sponsors This Study?

Lead: University of California, San Francisco

Collaborator Sponsor

  • National Institutes of Health (NIH)
  • National Institute on Aging (NIA)

Source: ID: NCT02966145

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