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Alzheimer's Biomarkers Consortium-Down Syndrome

Start: September 30, 2020
End: August 31, 2025
Enrollment: 500

What Is This Study About?

The Alzheimer's Biomarkers Consortium-Down Syndrome (ABC-DS) project is a large research initiative to find biomarkers to track Alzheimer's disease in people with Down syndrome. Over a five-year period, researchers will collect information and blood samples from people with Down syndrome and their siblings. Participants may undergo physical exams, neurological tests, brain scans, and assessments to measure cognition, memory, and movement. Additional information will be obtained through personal and family health history, caregiver questionnaires, and genetic studies. Information gained from this initiative may help people with Alzheimer's and Down syndrome, as well as people with only Alzheimer's disease.

Do I Qualify To Participate in This Study?

Minimum Age: 25

Maximum Age: NA

Must have:

  • Person with Down syndrome (full trisomy, partial trisomy, or mosaic Down syndrome)
  • Brother or sister of a person with Down syndrome
  • IQ of 30 or higher, according to Kaufman Brief Intelligence Test
  • Cognitively stable or mild cognitive impairment
  • Willingness to participate in study procedures including:
    • Cognitive and memory tests
    • Physical and neurological exams
    • Blood draw to identify biomarkers and collect DNA
    • Optional, but encouraged procedures include brain scans (MRI and positron emission tomography) and lumbar puncture to collect cerebrospinal fluid
  • Able to provide informed consent or have a legally authorized representative

Must NOT have:

  • Diagnosis of Alzheimer's disease or other type of dementia
  • Conditions that would interfere with cognitive assessments, including:
    • Unstable medical or a psychiatric condition
    • Severe motor or sensory impairment
  • IQ less than 30, according to Kaufman Brief Intelligence Test

If I Qualify, Who Do I Contact?

Contact study personnel listed either under the general study contact or the location nearest you.

 

Who Is the General Study Contact?

Below are the U.S. locations recruiting for this study. In addition, the University of Cambridge, in the United Kingdom, is also recruiting for this study. To contact them, please email Jessica Beresford-Webb
or Monika Grigorova or call +44-7547-348-323.

Need Help?

Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.

Where Is This Study Located?

California
University of California, Irvine
Irvine, CA 92697
Recruiting
Eric Doran
Kentucky
University of Kentucky
Lexington, KY 40506
Recruiting
Roberta Davis
Massachusetts
Massachusetts General Hospital
Boston, MA 02114
Recruiting
Courtney Jordan
Missouri
Washington University in Saint Louis
St. Louis, MO 63110
Recruiting
Brittany Nelson
New York
Columbia University Irving Medical Center New York
New York, NY 10032
Recruiting
Deborah Pang
New York State Institute for Basic Research in Developmental Disabilities
New York, NY 10314
Recruiting
Deborah Pang
Pennsylvania
University of Pittsburgh
Pittsburgh, PA 15260
Recruiting
Cathy Wolfe
Wisconsin
University of Wisconsin-Madison
Madison, WI 53705
Recruiting
Renee Makuch

Who Sponsors This Study?

Lead: University of Pittsburgh

Collaborator Sponsor

  • National Institute on Aging
  • National Institutes of Health, Office of the Director
  • National Institute of Child Health and Human Development
  • University of California, Irvine
  • University of Wisconsin - Madison