Alzheimer's Disease Neuroimaging Initiative 3 (ADNI3)

What Is This Study About?

The ADNI3 study is the third in a series of trials since 2004 to identify markers for diagnosis and tracking the progression of Alzheimer's disease. Diagnostic, clinical, cognitive, imaging, biomarker, and genetic characteristics will be assessed across three groups of participants: cognitively normal, MCI, and mild Alzheimer's dementia. Investigators will evaluate changes in participants' cognition (including memory, reasoning, and language). Participants will undergo clinical, cognitive, and genetic tests, as well as positron emission tomography (PET) and magnetic resonance imaging (MRI) brain scans and cerebrospinal fluid collection for up to five years.

Do I Qualify To Participate in This Study?

Must have:

All New Participants

• Good general health
• Study partner who has frequent contact with participant (minimum average of 10 hours per week) and can accompany participant to clinic visits
• Modified Hachinski Ischemic Score of less than or equal to 4; Geriatric Depression Scale score of less than 6
• Completion of six grades of education or good work history
• Willing to undergo repeated MRIs, at least two PET scans, blood collection, and at least one lumbar puncture
• Willing to share genetic data and biomarker samples
• Fluent in English or Spanish

Cognitively Normal Participants

• Cognitively normal, based on absence of significant impairment in cognitive function or activities of daily living (currently recruiting non-Caucasian participants only for the normal cognition group)
• With or without subjective memory complaints
• Normal memory function score; Mini-Mental State Examination (MMSE) score of 24-30 (exceptions considered for less than 8 years of education); Clinical Dementia Rating of 0; Memory Box score of 0

Participants with MCI

• Subjective memory concern reported by participant, study partner, or clinician
• Abnormal memory function score; MMSE score of 24-30 (exceptions considered for less than 8 years of education); Clinical Dementia Rating of 0.5; Memory Box score of at least 0.5
• General cognition and functional performance such that a diagnosis of Alzheimer's disease cannot be made by the site physician
• Permitted medications if taking at least 4 weeks: stable dose of antidepressants lacking significant anticholinergic effects, cholinesterase inhibitors or memantine, estrogen replacement therapy, gingko biloba; must discontinue psychoactive medications at least four weeks before screening

Participants with Alzheimers Disease

• Subjective memory concern reported by participant, study partner, or clinician
• Abnormal memory function score; MMSE score of 20-24 (exceptions considered for less than 8 years of education); Clinical Dementia Rating of 0.5 or 1.0
• Meets criteria for probable Alzheimers disease
• Permitted medications if taking at least 4 weeks: same as for MCI above

Must NOT have:

• Significant neurological disease other than Alzheimer's disease, such as Parkinson's disease, multi-infarct dementia, Huntington's disease, normal pressure hydrocephalus, brain tumor, progressive supranuclear palsy, seizure disorder, subdural hematoma, multiple sclerosis, or history of significant head trauma followed by persistent neurological deficits or known structural brain abnormalities
• Screening/baseline MRI brain scan with evidence of infection, infarction or other focal lesions, or multiple lacunes or lacunes in a critical memory structure
• Contraindications to MRI including pacemaker or metal fragments or foreign objects in the eyes, skin, or body
• Major depression or bipolar disorder within the past year; psychotic features, agitation, or behavioral problems within the last three months; history of schizophrenia
• Current treatment for obsessive-compulsive disorder or attention deficit disorder
• Alcohol or substance abuse/dependence within the past two years
• Any significant systemic illness or unstable medical condition that could lead to difficulty participating in the study
• Pregnant, lactating, or of childbearing potential (women must be two years postmenopausal or surgically sterile)
• Clinically significant abnormalities in B12 or thyroid function tests
• Prohibited medications: psychoactive medications (certain antidepressants, neuroleptics, chronic anxiolytics, or sedative hypnotics); warfarin or other anticoagulants (such as dabigatran, rivaroxaban, and apixaban); investigational agents one month prior to entry and during the study
• Residence in skilled nursing facility
• Participation in clinical studies involving neuropsychological measures collected more than one time per year

If I Qualify, Who Do I Contact?

Contact study personnel listed either under the general study contact or the location nearest you.

 

Who Is the General Study Contact?

To find out more information about the ADNI3 study, please visit www.ADNI3.org.

Where Is This Study Located?

Alabama
University of Alabama, Birmingham Birmingham, AL 35294 Recruiting Loren Brown Ashley 205-975-2779 samanthabrown@uabmc.edu
Arizona
Banner Alzheimer's Institute Phoenix, AZ 85006 Recruiting David Parkhurst 602-839-6939 David.parkhurst@bannerhealth.com
Barrow Neurological Institute Phoenix, AZ 85013 Recruiting Angelica Garcia 602-406-3132 angelica.garcia@dignityhealth.org
Banner Sun Health Research Institute Sun City, AZ 85351 Recruiting Kelly Clark 623-832-6527 Kelly.Clark2@bannerhealth.com
California
University of California, Irvine Irvine, CA 92697 Recruiting Beatriz Yañez 949-824-3250 byanez@uci.edu
University of California, San Diego La Jolla, CA 920371707 Recruiting Mollie Paster 858-249-1329 mrpaster@ucsd.edu
Long Beach VA Neuropsychiatric Research Program Long Beach, CA 90822 Recruiting Sakineh (Parvin) Khalaghizadeh 562-826-8000 sakineh.khalaghizadeh@va.gov
University of Southern California Los Angeles, CA 900335310 Recruiting Nadine Diaz 323-442-7600 Nadine.Diaz@med.usc.edu
University of California, Los Angeles Los Angeles, CA 90095 Recruiting Celine Ossinalde 310-794-6191 cossinalde@mednet.ucla.edu
VA Palo Alto HSC / Stanford School of Medicine Palo Alto, CA 94304 Recruiting Joy Taylor 650-493-5000 joyt@stanford.edu
University of California, San Francisco San Francisco, CA 94158 Recruiting Morgan Blackburn 415-514-8745 morgan.blackburn@ucsf.edu
University of California, Davis Walnut Creek, CA 945985900 Recruiting Hongzheng Zhang 925-357-6914 hzzhang@ucdavis.edu
Connecticut
Yale University School of Medicine New Haven, CT 65103330 Recruiting Emmie Banks Emmie.banks@yale.edu
District of Columbia
Georgetown University Washington, DC 200072145 Recruiting Kelly McCann 202-687-0413 keb53@georgetown.edu
Howard University Washington, DC 200600001 Recruiting Saba Wolday 202-865-7895 swolday@howard.edu
Florida
Mayo Clinic, Jacksonville Jacksonville, FL 32224 Recruiting Sochenda Chea 904-953-3234 chea.sochenda@mayo.edu
Wien Center for Clinical Research Miami Beach, FL 331402877 Recruiting Maria Greig-Custo 305-674-2121 Maria.Greig-Custo@msmc.com
University of South Florida - Health Byrd Alzheimer Institute Tampa, FL 336134808 Recruiting Juris Janavs 813-396-0637 jjanavs@health.usf.edu
Georgia
Emory University Atlanta, GA 30322 Recruiting Rebecca Byram 404-712-0195 rbyram@emory.edu
Illinois
Northwestern University Chicago, IL 606113010 Recruiting Brittanie Muse 312-503-5674 Brittanie.muse@northwestern.edu
Rush University Medical Center Chicago, IL 606123806 Recruiting Erin Yurko 312-942-6596 erin_yurko@rush.edu
Indiana
Indiana University Indianapolis, IN 46202 Recruiting Christina Brown 317-963-7426 chbrown@iupui.edu
Iowa
University of Iowa Iowa City, IA 52242 Recruiting Karen Ekstam-Smith 319-353-5158 karen-ekstam@uiowa.edu
Kansas
University of Kansas Fairway, KS 66205 Recruiting Melissa Dodd 913-945-6792 mdodd@kumc.edu
Kentucky
University of Kentucky Lexington, KY 405042681 Recruiting Dorothy Ross 859-323-2737 dross3@email.uky.edu
Maryland
Johns Hopkins University Baltimore, MD 212242764 Recruiting Scott Rudow 443-287-0381 srudow2@jhmi.edu
Massachusetts
Brigham and Women's Hospital Boston, MA 21155804 Recruiting Nancy Coppelman 617-732-8085 ncoppelman@partners.org
Boston University School of Medicine Boston, MA 21182307 Recruiting Jane Mwicigi 617-358-6425 jmwicigi@bu.edu
Michigan
University of Michigan, Ann Arbor Ann Arbor, MI 481052967 Recruiting Sara Raymo 734-232-1199 sraymo@med.umich.edu
Minnesota
Mayo Clinic, Rochester Rochester, MN 559050001 Recruiting Colleen Albers 507-293-4866 Albers.Colleen@mayo.edu
Missouri
Washington University, St. Louis Saint Louis, MO 631082215 Recruiting David Winkfield 314-286-2429 davidwinkfield@wustl.edu
Nevada
Cleveland Clinic Lou Ruvo Center for Brain Health Las Vegas, NV 891060100 Recruiting Liliana Dumitrescu 702-483-6016 dumitrl@ccf.org
New York
Albany Medical College Albany, NY 12208 Recruiting Mary Eglow 518-264-1130 eglowm@mail.amc.edu
Dent Neurologic Institute Buffalo, NY 142261727 Recruiting Michelle Rainka 716-250-2038 mrainka@deninstitute.com
New York University Medical Center New York, NY 100166055 Recruiting Karen Castro Karen.castro2@nyulangone.org
Mount Sinai School of Medicine New York, NY 100296552 Recruiting Jonathan Greenberg 212-659-5621 jonathan.greenberg@mssm.edu
Columbia University New York, NY 10032 Recruiting Anton Kociolek 212-342-0522 ak3951@cumc.columbia.edu
Nathan Kline Institute for Psychiatric Research Orangeburg, NY 109621159 Recruiting Antero Sarreal 845-398-6532 asarreal@nki.rfmh.org
University of Rochester Rochester, NY 14620 Recruiting Nancy Kowalski 585-760-6569 nancy_kowalski@urmc.rochester.edu
North Carolina
Duke University Medical Center Durham, NC 27710 Recruiting Cammie Hellegers 919-681-3986 caroline.hellegers@duke.edu
Wake Forest University Health Sciences Winston-Salem, NC 27157 Recruiting Bevan Hoover 336-713-9868 beehoover@wakehealth.edu
Ohio
Case Western Reserve University Beachwood, OH 441224312 Recruiting Parianne Fatica 216-464-6474 parianne.fatica@uhhospitals.org
Ohio State University Columbus, OH 43210 Recruiting Jennifer Icenhour 614-293-6882 jennifer.icenhour@osumc.edu
Oregon
Oregon Health & Science University Portland, OR 972393011 Recruiting Rachel Crissey 503-494-0976 crissey@ohsu.edu
Pennsylvania
University of Pennsylvania Philadelphia, PA 19104 Recruiting Grace Stockbower 215-746-3949 Grace.stockbower@uphs.upenn.edu
University of Pittsburgh Pittsburgh, PA 15213 Recruiting MaryAnn Oakley 412-692-2721 oakleym@upmc.edu
Rhode Island
Rhode Island Hospital Providence, RI 02903 Recruiting Terry Fogerty 401-606-4664 TFogerty@lifespan.org
Butler Hospital Memory and Aging Program Providence, RI 02906 Recruiting Tara Tang 401-455-6403 TTang@Butler.org
South Carolina
Roper St. Francis Hospital Charleston, SC 29401 Recruiting Allison Lapp 843-724-2214 allison.lapp@rsfh.com
Tennessee
Vanderbilt University Medical Center Nashville, TN 37212 Recruiting Xuewen Gong 615-343-1567 Xuewen.gong.1@vumc.org
Texas
University of Texas, Southwestern MC at Dallas Dallas, TX 75390 Recruiting Amy Browning 214-645-1972 amy.browning@utsouthwestern.edu
Baylor College of Medicine Houston, TX 77030 Recruiting Nat Pacini 713-798-5328 nat.pacini@bcm.edu
Houston Methodist Houston, TX 77030 Recruiting Jennifer Garrett 713-441-9484 jmgarrett@houstonmethodist.org
Wisconsin
University of Wisconsin Madison, WI 537920001 Recruiting Sandra Harding 608-262-4760 sjharding@medicine.wisc.edu

Who Sponsors This Study?

Lead: University of Southern California

Collaborator Sponsor

• Northern California Institute of Research and Education
• National Institute on Aging (NIA)
• Alzheimer's Therapeutic Research Institute

Source: ClinicalTrials.gov ID: NCT02854033