Alzheimer's Prevention Through Exercise
Start: November 2013
End: December 31, 2019
Enrollment: 100
What Is This Study About?
The purpose of this study is to learn about the possible benefits of aerobic exercise for individuals at risk of developing Alzheimer's disease.
Do I Qualify To Participate in This Study?
Minimum Age: 65 Years
Maximum Age: N/A
Must have:
- Clinical Dementia Rating score of 0 (nondemented)
- Brain scan (florbetapir PET) evidence of cerebral amyloidosis
- Sedentary or underactive, as determined by the Telephone Assessment of Physical Activity
- If taking medications, on stable doses for at least 30 days
- Ability to complete the 1-year exercise intervention
Must NOT have:
- Clinically significant major psychiatric disorder, such as major depression, or psychiatric symptoms that could impair completion of the study
- Clinically significant systemic illness that may affect safety or completion of the study
- History of clinically evident stroke
- Clinically significant infection within the last 30 days
- Active cardiac condition (such as angina, myocardial infarction, atrial fibrillation) or pulmonary condition within the past 2 years that could pose a safety risk to the participant, unless cleared for exercise by the participant's primary care physician or cardiologist
- Uncontrolled hypertension within the last 6 months
- History of drug or alcohol abuse within the last 2 years
- Insulin-dependent diabetes mellitus
- Significant pain or musculoskeletal disorder prohibiting participation in an exercise program
- Unwillingness to undergo or contraindication to brain MRI scan
- History within the last 5 years of cancer or primary/recurrent malignant disease, with the exception of resected localized cutaneous squamous cell carcinoma, nonmetastatic basal cell carcinoma, cervical carcinoma, or prostate cancer
If I Qualify, Who Do I Contact?
Contact study personnel listed either under the general study contact or the location nearest you.
Need Help?
Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.
Where Is This Study Located?
Who Sponsors This Study?
Lead: University of Kansas
Collaborator Sponsor
- National Institute on Aging (NIA)
Source: ClinicalTrials.gov ID: NCT02000583