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Alzheimer's Prevention Through Exercise

Start: November 2013
End: December 31, 2019
Enrollment: 100

What Is This Study About?

The purpose of this study is to learn about the possible benefits of aerobic exercise for individuals at risk of developing Alzheimer's disease.

Do I Qualify To Participate in This Study?

Minimum Age: 65 Years

Maximum Age: N/A

Must have:

  • Clinical Dementia Rating score of 0 (nondemented)
  • Brain scan (florbetapir PET) evidence of cerebral amyloidosis
  • Sedentary or underactive, as determined by the Telephone Assessment of Physical Activity
  • If taking medications, on stable doses for at least 30 days
  • Ability to complete the 1-year exercise intervention

Must NOT have:

  • Clinically significant major psychiatric disorder, such as major depression, or psychiatric symptoms that could impair completion of the study
  • Clinically significant systemic illness that may affect safety or completion of the study
  • History of clinically evident stroke
  • Clinically significant infection within the last 30 days
  • Active cardiac condition (such as angina, myocardial infarction, atrial fibrillation) or pulmonary condition within the past 2 years that could pose a safety risk to the participant, unless cleared for exercise by the participant's primary care physician or cardiologist
  • Uncontrolled hypertension within the last 6 months
  • History of drug or alcohol abuse within the last 2 years
  • Insulin-dependent diabetes mellitus
  • Significant pain or musculoskeletal disorder prohibiting participation in an exercise program
  • Unwillingness to undergo or contraindication to brain MRI scan
  • History within the last 5 years of cancer or primary/recurrent malignant disease, with the exception of resected localized cutaneous squamous cell carcinoma, nonmetastatic basal cell carcinoma, cervical carcinoma, or prostate cancer

If I Qualify, Who Do I Contact?

Contact study personnel listed either under the general study contact or the location nearest you.


Need Help?

Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.

Where Is This Study Located?

Who Sponsors This Study?

Lead: University of Kansas

Collaborator Sponsor

  • National Institute on Aging (NIA)

Source: ID: NCT02000583