Start: December 18, 2018
End: February 28, 2022
Disruption of the blood-brain barrier, which is important for protecting the brain, could be an early process that precedes Alzheimer's disease. This study will test a method for measuring disruptions to the blood-brain barrier using advanced magnetic resonance imaging (MRI) methods in cognitively normal younger and older adults and adults with mild cognitive impairment (MCI), a condition that puts people at higher risk for Alzheimer's. Participants will undergo an MRI brain scan for up to 60 minutes that employs an imaging technique called GRASP DCE-MRI (golden-angle radial sparse parallel dynamic contrast agent-enhanced MRI). Researchers will compare the patterns of blood-brain barrier permeability, or disruption, in normal versus abnormal aging.
Minimum Age: 20 Years
Maximum Age: 85 Years
Contact study personnel listed either under the general study contact or the location nearest you.
New York University School of Medicine
New York, NY 10016
Lead: NYU Langone Health
Source: ClinicalTrials.gov ID: NCT03389698