Start: July 16, 2018
End: April 2026
This study will compare the effects of different diets on cognition, brain blood flow, and Alzheimer's biomarkers in adults with mild cognitive impairment (MCI). Participants will be randomly assigned to follow either a low-carbohydrate or a low-fat diet for four months, with follow-up assessment eight weeks after diet completion. The diets will be individually planned with help from a study dietitian. In general, the low-carbohydrate, high-fat diet will be a modified Mediterranean-ketogenic diet consisting of fish, lean meats, nutrient-rich foods, olive oil, and less than 20 grams of carbohydrates daily. Participants in the low-fat, high-carbohydrate diet (American Heart Association Diet) will be encouraged to limit fat intake to less than 40 grams per day, while eating plenty of fruits, vegetables, and fiber-containing carbohydrates. All participants will receive a daily multivitamin.
Minimum Age: 55 Years
Maximum Age: 85 Years
Contact study personnel listed either under the general study contact or the location nearest you.
Wake Forest Baptist Medical Center
Winston-Salem, NC 27157
RecruitingSarah Bohlman, MS
Lead: Wake Forest University Health Sciences
Source: ClinicalTrials.gov ID: NCT03472664