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Brain Imaging for Obesity and Alzheimer's Disease Risk

Start: October 15, 2021
End: December 31, 2026
Enrollment: 240

What Is This Study About?

High body fat at midlife is increasingly understood as a risk factor for Alzheimer's disease. This study will use brain imaging to identify changes associated with Alzheimer's in the brains of middle-aged people with normal cognition. Participants will be assigned to one of three groups: 1) metabolically abnormal overweight and obese, 2) metabolically normal overweight and obese, or 3) metabolically normal lean based on blood tests to evaluate their metabolism, or how efficiently they convert food to energy. All participants will undergo MRI and PET brain imaging to evaluate changes in brain structure, visualize abnormal proteins, and detect brain inflammation. This information will be used to identify brain changes or biomarkers that can be used in future studies about obesity and Alzheimer's risk.

Do I Qualify To Participate in This Study?

Minimum Age: 40 Years

Maximum Age: 60 Years

Must have:

  • Normal cognition with a Mini-Mental State Examination score > 25 or a Clinical Dementia Rating Scale score of 0
    • Willing to be categorized for the study as either metabolically abnormal overweight and obese, metabolically normal overweight and obese, or metabolically normal lean based on body mass index and metabolic testing

    Must NOT have:

    • Any medical condition that could limit participation or interfere with data collection, or make brain imaging procedures unsafe, including:
      • Allergies or sensitivities to the PET scan radioactive tracers [11C] PiB or [18F] AV-1451
      • Metal shrapnel or implanted devices (e.g., heart pacemaker)
      • Severe claustrophobia
      • Body circumference > 165 cm (~65 inches)
      • Unable to tolerate lying still during the brain scanning procedures (e.g., severe, chronic back pain)
    • Women who are currently pregnant or breastfeeding
    • Currently taking an obesity drug or in another obesity clinical trial
    • Intention to have bariatric surgery
    • History of type 1 or 2 diabetes
    • Unable to receive IV injections or blood draws

    If I Qualify, Who Do I Contact?

    Contact study personnel listed either under the general study contact or the location nearest you.

     
    Study Contact
    Cyrus Raji, MD, PhD
    Nancy Hantler, BS, CCRC, ACRP-PM

    Need Help?

    Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.

    Where Is This Study Located?

    Missouri
    Washington University School of Medicine
    Saint Louis, MO 63110
    Recruiting
    LaKisha A Lloyd, MS

    Who Sponsors This Study?

    Lead: Cyrus A Raji

    Source: ClinicalTrials.gov ID: NCT05077579