Skip to main content
Find more clinical trials

Candesartan vs. Lisinopril Effects on the Brain (CALIBREX)

Start: August 2014
End: December 3, 2018
Enrollment: 140

What Is This Study About?

This study will compare the effects of two high blood pressure medications, candesartan and lisinopril, on the brains of people with high blood pressure and executive mild cognitive impairment. Changes in executive function, neuroimaging markers, and vascular indicators will be measured.

Do I Qualify To Participate in This Study?

Minimum Age: 60 Years

Maximum Age: N/A

Must have:

  • High blood pressure (systolic blood pressure ≥140 mm Hg, diastolic blood pressure ≥90 mm Hg, or taking antihypertensive medications)
  • Executive mild cognitive impairment, defined using these criteria: 1) Montreal Cognitive Assessment score of less than 26; 2) Clinical Dementia Rating score of 0.5; 3) Performance at the 10th percentile or below on at least one of four screening tests for executive function: Trail Making Test, Part B (TMT-B), modified Stroop interference, verbal fluency (number of D words in 1 minute) or abstractions

Must NOT have:

  • Intolerance to study drugs
  • Systolic blood pressure of >200 mm Hg or diastolic blood pressure of >110 mm Hg
  • Renal disease or hyperkalemia 4
  • Active medical or psychiatric problems
  • Uncontrolled congestive heart failure
  • History of stroke in the past 3 years
  • Women of childbearing potential
  • Use of acetylcholinesterase inhibitors or NMDA receptor antagonist (memantine)

If I Qualify, Who Do I Contact?

Contact study personnel listed either under the general study contact or the location nearest you.


Need Help?

Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.

Where Is This Study Located?

Who Sponsors This Study?

Lead: Emory University

Collaborator Sponsor

  • National Institute on Aging (NIA)

Source: ID: NCT01984164