Start: February 2015
End: January 2021
What Is This Study About?
This observational study will characterize the biological mechanisms contributing to cognitive impairment and decline in older adults with depression. No treatment will be tested or given.
Do I Qualify To Participate in This Study?
- Current DSM-IV diagnosis of major depressive disorder, unipolar type, without psychotic features, of at least 6 weeks' duration
- English speaking
- Hamilton Depression Rating Scale score of 15
- Willing to undergo magnetic resonance imaging (MRI) and positron emission tomography (PET) brain scans; able to fit comfortably in an MRI machine
- Agrees to collection of blood for genetic and biomarker testing, assays, and telomere length measurement
- Seeing and hearing ability adequate for neuropsychological testing
- Completed six grades of education or has established work history sufficient to exclude mental retardation
- Available study partner who has frequent contact with participant (average of 10 or more hours per week) and can accompany him or her to clinical visits
Must NOT have:
- Current diagnosis of other axis 1 psychiatric disorders, with the exception of simple phobias and generalized anxiety disorder
- Evidence of dementia (MMSE score <25)
- Any electroconvulsive therapy within the past 6 months
- Undergoing antidepressant or psychotherapy treatment
- Any significant neurological diseases, such as Parkinson's disease, epilepsy, cortical stroke, or traumatic brain injury
- History of alcohol or substance abuse or dependence within the past 2 years
- Any active and serious suicidal ideation
- Any significant systemic illness or unstable medical condition that could lead to difficulty complying with study procedures
- History of surgical procedures effecting study outcomes
- Residence in skilled nursing facility
- Participation in clinical studies involving the same neuropsychological measures used in ADNI-D
- Current or recent participation in any procedures involving radioactive agents such that the total radiation dose exposure to the subject in any given year would exceed federal limits; known history of MRI scans with evidence of infection, infarction, or other focal lesions; multiple lacunes or lacunes in a critical memory structure; presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments, or foreign objects in the eyes, skin or body, claustrophobia
- Pregnant, lactating, or of childbearing potential (women must be 2 years post-menopausal or surgically sterile)
If I Qualify, Who Do I Contact?
Contact study personnel listed either under the general study contact or the location nearest you.
Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.
Where Is This Study Located?
Lead: Alzheimer's Therapeutic Research Institute
National Institute of Mental Health (NIMH)
University of California, San Francisco
University of Southern California
Source: ClinicalTrials.gov ID: NCT02434393