Start: November 29, 2017
End: July 31, 2023
What Is This Study About?
This study will evaluate the effects of computer-based cognitive training on everyday cognitive function in older adults with memory loss. In this 18-month study, participants will be randomly assigned to computer-based cognitive training or to crossword puzzle training that can be completed at home. Participants will be asked to visit the memory clinic for screening and follow-up visits to assess changes in memory and cognitive function.
Do I Qualify To Participate in This Study?
- Memory or other cognitive complaints
- Cognitive impairment as measured by the Wechsler Memory Scale III Logical Memory test
- Mini-Mental State Examination score of 23 or more
- Individual who can serve as a study informant (can be via telephone)
- Access to a home computer and acceptable Internet speed for study duration
- English speaking
Must NOT have:
- Diagnosis of dementia
- Schizophrenia, schizoaffective disorder, major depression, psychosis, or bipolar I disorder
- Active suicidal ideation or plan
- Alcohol or substance use disorder in past six months
- Clinical stroke with residual neurological deficits
- Prohibited medications: benzodiazepines in lorazepam equivalents of 1 mg or more daily, narcotics, and anticholinergics
- Central nervous system infection, with cerebrospinal fluid evidence of meningitis, encephalitis, or other infectious process
- Dementia of any type, Huntington's disease, multiple sclerosis, Parkinson's disease, other neurological disorders with focal signs (e.g., amyotrophic lateral sclerosis). and mental retardation
- Severe unstable medical illness (successfully treated cancer is not exclusionary)
- Inability to undergo MRI scan, including pacemaker and metal implants
- Online brain training or crossword puzzle use two or more times per week in past year (must also refrain from these activities during the study)
- Participation in another intervention trial for cognitive impairment
If I Qualify, Who Do I Contact?
Contact study personnel listed either under the general study contact or the location nearest you.
Jessica L D'Antonio, BA
Laura Simon-Pearson, BA
Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.
Where Is This Study Located?
Lead: New York State Psychiatric Institute
Queens College, The City University of New York
Source: ClinicalTrials.gov ID: NCT03205709