Cognitive Training and Neuroplasticity in Mild Cognitive Impairment

What Is This Study About?

This study will evaluate the effects of computer-based cognitive training on everyday cognitive function in older adults with memory loss. In this 18-month study, participants will be randomly assigned to computer-based cognitive training or to crossword puzzle training that can be completed at home. Participants will be asked to visit the memory clinic for screening and follow-up visits to assess changes in memory and cognitive function.

Do I Qualify To Participate in This Study?

Must have:

• Memory or other cognitive complaints
• Cognitive impairment as measured by the Wechsler Memory Scale III Logical Memory test
• Mini-Mental State Examination score of 23 or more
• Individual who can serve as a study informant (can be via telephone)
• Access to a home computer and acceptable Internet speed for study duration
• English speaking

Must NOT have:

• Diagnosis of dementia
• Schizophrenia, schizoaffective disorder, major depression, psychosis, or bipolar I disorder
• Active suicidal ideation or plan
• Alcohol or substance use disorder in past six months
• Clinical stroke with residual neurological deficits
• Prohibited medications: benzodiazepines in lorazepam equivalents of 1 mg or more daily, narcotics, and anticholinergics
• Central nervous system infection, with cerebrospinal fluid evidence of meningitis, encephalitis, or other infectious process
• Dementia of any type, Huntington's disease, multiple sclerosis, Parkinson's disease, other neurological disorders with focal signs (e.g., amyotrophic lateral sclerosis). and mental retardation
• Severe unstable medical illness (successfully treated cancer is not exclusionary)
• Inability to undergo MRI scan, including pacemaker and metal implants
• Online brain training or crossword puzzle use two or more times per week in past year (must also refrain from these activities during the study)
• Participation in another intervention trial for cognitive impairment

If I Qualify, Who Do I Contact?

Contact study personnel listed either under the general study contact or the location nearest you.

 

Where Is This Study Located?

Who Sponsors This Study?

Lead: New York State Psychiatric Institute

Collaborator Sponsor

• Duke University
• Queens College, The City University of New York

Source: ClinicalTrials.gov ID: NCT03205709