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Cognitive Training and Neuroplasticity in Mild Cognitive Impairment

Start: November 29, 2017
End: July 31, 2023
Enrollment: 100

What Is This Study About?

This study will evaluate the effects of computer-based cognitive training on everyday cognitive function in older adults with memory loss. In this 18-month study, participants will be randomly assigned to computer-based cognitive training or to crossword puzzle training that can be completed at home. Participants will be asked to visit the memory clinic for screening and follow-up visits to assess changes in memory and cognitive function.

Do I Qualify To Participate in This Study?

Minimum Age: 55 Years

Maximum Age: 95 Years

Must have:

  • Memory or other cognitive complaints
  • Cognitive impairment as measured by the Wechsler Memory Scale III Logical Memory test
  • Mini-Mental State Examination score of 23 or more
  • Individual who can serve as a study informant (can be via telephone)
  • Access to a home computer and acceptable Internet speed for study duration
  • English speaking

Must NOT have:

  • Diagnosis of dementia
  • Schizophrenia, schizoaffective disorder, major depression, psychosis, or bipolar I disorder
  • Active suicidal ideation or plan
  • Alcohol or substance use disorder in past six months
  • Clinical stroke with residual neurological deficits
  • Prohibited medications: benzodiazepines in lorazepam equivalents of 1 mg or more daily, narcotics, and anticholinergics
  • Central nervous system infection, with cerebrospinal fluid evidence of meningitis, encephalitis, or other infectious process
  • Dementia of any type, Huntington's disease, multiple sclerosis, Parkinson's disease, other neurological disorders with focal signs (e.g., amyotrophic lateral sclerosis). and mental retardation
  • Severe unstable medical illness (successfully treated cancer is not exclusionary)
  • Inability to undergo MRI scan, including pacemaker and metal implants
  • Online brain training or crossword puzzle use two or more times per week in past year (must also refrain from these activities during the study)
  • Participation in another intervention trial for cognitive impairment

If I Qualify, Who Do I Contact?

Contact study personnel listed either under the general study contact or the location nearest you.


Need Help?

Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.

Where Is This Study Located?

Who Sponsors This Study?

Lead: New York State Psychiatric Institute

Collaborator Sponsor

  • Duke University
  • Queens College, The City University of New York

Source: ID: NCT03205709