Skip to main content
U.S. flag

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock (  ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Find more clinical trials

Computer-Based Cognition Test To Detect Early-Stage Alzheimer's Disease

Start: 12/14/2018
End: 12/13/2022
Enrollment: 240

What Is This Study About?

Researchers have found that more people with mild cognitive impairment (MCI) than those without it go on to develop Alzheimer's disease or a related dementia. This study will evaluate whether the computer-based Cognitive Stress Test can effectively detect early-stage MCI to help identify people at risk for developing Alzheimer's disease. All participants will take computer-based and traditional cognition tests, and receive PET and MRI brain scans. Researchers will compare the cognitive function test results with the physical signs associated with Alzheimer's disease, including the amounts of abnormal tau and amyloid proteins in the brain and the size and thickness of certain brain regions.

Do I Qualify To Participate in This Study?

Minimum Age: 60

Maximum Age: None

Must have:

  • Participants must have either:
    • Mild cognitive impairment with:
      • Memory problems, as confirmed by a person who knows the participant well
      • No impairment in social or occupational functions
      • No evidence of a major neurocognitive disorder
    • Normal cognition with no memory problems, as confirmed by a person who knows the participant well
  • Speak English or Spanish as their primary language

Must NOT have:

  • Significant sensory or movement problems (e.g., visual or hearing impairment, paralysis)
  • Diagnosis of a serious psychological disorder (e.g., major depression, bipolar disorder, psychotic disorder, substance use disorder)

If I Qualify, Who Do I Contact?

Contact study personnel listed either under the general study contact or the location nearest you.

Study Contact
Martin Orkuma
David Loewenstein, PhD

Need Help?

Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.

Where Is This Study Located?

University of Miami, Center for Cognitive Neuroscience and Aging
Miami, FL 33136
Martin Orkuma

Who Sponsors This Study?

Lead: University of Miami

Collaborator Sponsor

  • National Institute on Aging

An official website of the U.S. government, managed by the National Institute on Aging at the National Institutes of Health