Start: January 2014
End: December 2020
What Is This Study About?
This study will determine the impact of two interventions in people with early memory problems. First, it will test the clinical benefits of curcumin, a compound isolated from turmeric root, a component of Indian curry spices that has been found to inhibit several potential pathways in Alzheimer's disease. Second, it will determine the effect of adding a yoga-based physical exercise program.
Do I Qualify To Participate in This Study?
- Subjective cognitive complaints
- Mini-Mental Status Exam (MMSE) score of 24; performance 1.5 standard deviation below average on Consortium to Establish a Registry for Alzheimer's Disease (CERAD) word list learning test
- Essentially intact activities of daily living
- Sedentary (exercise less than 30 minutes a day, 3 times a week)
- Able to exercise safely without cardiovascular symptoms and pass a graded treadmill test modified for the elderly
- Community dwelling
- Fluent in written and spoken English
Must NOT have:
- Diagnosis of dementia
- Concurrent substance abuse disorder, psychosis, or mood disorder
- Neurological disease affecting motor or cognitive abilities (such as Parkinson's disease) or other significant uncontrolled medical problems
- Initiation of any new medication/treatment for cognitive impairment (such as cholinesterase inhibitor or memantine) less than 6 months prior to study enrollment
If I Qualify, Who Do I Contact?
Contact study personnel listed either under the general study contact or the location nearest you.
Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.
Where Is This Study Located?
Lead: VA Office of Research and Development
Source: ClinicalTrials.gov ID: NCT01811381