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Find more clinical trials

Cycling Exercise for Treating Alzheimer's Disease

Start: January 2014
End: April 2021
Enrollment: 90

What Is This Study About?

This clinical trial will investigate the effects of a 6-month cycling exercise program on cognition and hippocampal volume in older adults with Alzheimer's disease. Researchers want to determine if the intervention can slow cognitive decline.

Do I Qualify To Participate in This Study?

Minimum Age: 66 Years

Maximum Age: N/A

Must have:

  • Diagnosis of probable or possible Alzheimer's disease
  • Mini-Mental State Examination (MMSE) score of 15-26 inclusive; Clinical Dementia Rating score of 0.5-2
  • Community-dwelling (includes assisted living)
  • English-speaking
  • Approved to participate by primary care provider and cardiologist if there is significant cardiac history
  • Alzheimer's drugs allowable if on stable dose for at least 1 month

Must NOT have:

  • Resting heart rate of ≤50 or ≥100 beats/minute
  • Neurological or psychiatric disorder in the past 5 years
  • Alcohol or chemical dependency in the past 5 years
  • Contraindications to exercise
  • New symptoms or diseases that have not been evaluated by a health care provider, for example, hip fracture, ongoing and unplanned weight loss, severe shortness of breath, deep vein thrombosis, hernia, unhealed sores, joint swelling, pain, or trouble walking
  • Cardiac ischemia or serious arrhythmia shown by electrocardiograph during the screening exercise test

If I Qualify, Who Do I Contact?

Contact study personnel listed either under the general study contact or the location nearest you.


Need Help?

Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.

Where Is This Study Located?

Who Sponsors This Study?

Lead: University of Minnesota-Clinical and Translational Science Institute

Collaborator Sponsor

  • Mayo Clinic
  • University of St. Thomas

Source: ID: NCT01954550

An official website of the U.S. government, managed by the National Institutes on Aging at the National Institutes of Health