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Cycling Exercise for Treating Alzheimer's Disease

Start: January 2014
End: April 30, 2021
Enrollment: 90

What Is This Study About?

This clinical trial will investigate the effects of a 6-month cycling exercise program on cognition and hippocampal volume in older adults with Alzheimer's disease. Researchers want to determine if the intervention can slow cognitive decline.

Do I Qualify To Participate in This Study?

Minimum Age: 66 Years

Maximum Age: N/A

Must have:

  • Diagnosis of probable or possible Alzheimer's disease
  • Mini-Mental State Examination (MMSE) score of 15-26 inclusive; Clinical Dementia Rating score of 0.5-2
  • Community-dwelling (includes assisted living)
  • English-speaking
  • Approved to participate by primary care provider and cardiologist if there is significant cardiac history
  • Alzheimer's drugs allowable if on stable dose for at least 1 month

Must NOT have:

  • Resting heart rate of ≤50 or ≥100 beats/minute
  • Neurological or psychiatric disorder in the past 5 years
  • Alcohol or chemical dependency in the past 5 years
  • Contraindications to exercise
  • New symptoms or diseases that have not been evaluated by a health care provider, for example, hip fracture, ongoing and unplanned weight loss, severe shortness of breath, deep vein thrombosis, hernia, unhealed sores, joint swelling, pain, or trouble walking
  • Cardiac ischemia or serious arrhythmia shown by electrocardiograph during the screening exercise test
Study Contact
Susan Greimel

Need Help?

Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.

Where Is This Study Located?

University of Minnesota
Minneapolis, MN 55455

Who Sponsors This Study?

Lead: University of Minnesota-Clinical and Translational Science Institute

Collaborator Sponsor

  • Mayo Clinic
  • University of St. Thomas

Source: ID: NCT01954550