Start: January 2014
End: April 30, 2021
What Is This Study About?
This clinical trial will investigate the effects of a 6-month cycling exercise program on cognition and hippocampal volume in older adults with Alzheimer's disease. Researchers want to determine if the intervention can slow cognitive decline.
Do I Qualify To Participate in This Study?
- Diagnosis of probable or possible Alzheimer's disease
- Mini-Mental State Examination (MMSE) score of 15-26 inclusive; Clinical Dementia Rating score of 0.5-2
- Community-dwelling (includes assisted living)
- Approved to participate by primary care provider and cardiologist if there is significant cardiac history
- Alzheimer's drugs allowable if on stable dose for at least 1 month
Must NOT have:
- Resting heart rate of ≤50 or ≥100 beats/minute
- Neurological or psychiatric disorder in the past 5 years
- Alcohol or chemical dependency in the past 5 years
- Contraindications to exercise
- New symptoms or diseases that have not been evaluated by a health care provider, for example, hip fracture, ongoing and unplanned weight loss, severe shortness of breath, deep vein thrombosis, hernia, unhealed sores, joint swelling, pain, or trouble walking
- Cardiac ischemia or serious arrhythmia shown by electrocardiograph during the screening exercise test
Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.
Where Is This Study Located?
University of Minnesota
Minneapolis, MN 55455
Lead: University of Minnesota-Clinical and Translational Science Institute
University of St. Thomas
Source: ClinicalTrials.gov ID: NCT01954550