Cycling Exercise for Treating Alzheimer's Disease

What Is This Study About?

This clinical trial will investigate the effects of a 6-month cycling exercise program on cognition and hippocampal volume in older adults with Alzheimer's disease. Researchers want to determine if the intervention can slow cognitive decline.

Do I Qualify To Participate in This Study?

Must have:

• Diagnosis of probable or possible Alzheimer's disease
• Mini-Mental State Examination (MMSE) score of 15-26 inclusive; Clinical Dementia Rating score of 0.5-2
• Community-dwelling (includes assisted living)
• English-speaking
• Approved to participate by primary care provider and cardiologist if there is significant cardiac history
• Alzheimer's drugs allowable if on stable dose for at least 1 month

Must NOT have:

• Resting heart rate of ≤50 or ≥100 beats/minute
• Neurological or psychiatric disorder in the past 5 years
• Alcohol or chemical dependency in the past 5 years
• Contraindications to exercise
• New symptoms or diseases that have not been evaluated by a health care provider, for example, hip fracture, ongoing and unplanned weight loss, severe shortness of breath, deep vein thrombosis, hernia, unhealed sores, joint swelling, pain, or trouble walking
• Cardiac ischemia or serious arrhythmia shown by electrocardiograph during the screening exercise test

If I Qualify, Who Do I Contact?

Contact study personnel listed either under the general study contact or the location nearest you.

 

Where Is This Study Located?

Who Sponsors This Study?

Lead: University of Minnesota-Clinical and Translational Science Institute

Collaborator Sponsor

• Mayo Clinic
• University of St. Thomas

Source: ClinicalTrials.gov ID: NCT01954550