Start: January 2009
End: July 2024
Enrollment: 600
This study will identify the biological changes that occur in the development of Alzheimer's disease to improve early diagnosis and to track progression of the disease. Researchers will collect biological information from adults who have parents a known inheritable, genetic mutation for Alzheimer's disease, specifically mutations in presenilin 1 (PSEN1), presenilin 2 (PSEN2), and amyloid precursor protein (APP) genes. Participants will undergo genetic testing, brain imaging, and provide blood and spinal fluid samples. Researchers will measure the amount of abnormal amyloid in the brain and spinal fluid, changes in brain size (e.g. shrinkage), and brain metabolism (energy processing). They will compare the changes that occur in participants with and without mild Alzheimer's symptoms, who may or may not have an Alzheimer's genetic mutation. All results will be stored in the Dominantly Inherited Alzheimer's Network (DIAN) Central Archive, an international database that allows qualified researchers to access and analyze the information. All information will be anonymized to ensure the privacy of the participants. Participants may choose to receive the results of their genetic test, and if so, will have access to genetic counseling at no cost.
Minimum Age: 18 Years
Maximum Age: N/A
Contact study personnel listed either under the general study contact or the location nearest you.
Study Contact
DIAN Global Coordinator
314-747-1940
olivera@abraxas.wustl.edu
Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.
Florida | |
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Mayo Clinic Jacksonville
Jacksonville, FL 32224
Recruiting
Sochenda Chea, BHA CRC904-953-3234 chea.sochenda@mayo.edu |
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Indiana | |
Indiana University-Indiana Alzheimer Disease Center
Indianapolis, IN 46202
Recruiting
Jill Buck, RN317-963-1847 jilmbuck@iu.edu |
|
Massachusetts | |
Brigham and Women's Hospital
Boston, MA 02115
Recruiting
Paige Sparks, BA617-643-7799 kpsparks@bwh.harvard.edu |
|
Missouri | |
Washington University School of Medicine
Saint Louis, MO 63108
Recruiting
Wendy Sigurdson, RN, MPH314-362-2256 sigurdsonw@neuro.wustl.edu |
|
New York | |
Columbia University
New York, NY 10032
Recruiting
Katie Neimeyer212-305-5909 Kn2416@cumc.columbia.edu |
|
Pennsylvania | |
University of Pittsburgh
Pittsburgh, PA 15260
Recruiting
Zana Ikonomovic, MD412-692-2740 ikonomovics@upmc.edu |
|
Rhode Island | |
Butler Hospital
Providence, RI 02906
Recruiting
Courtney Bodge, PhD401-455-6403 cbodge@butler.org |
Lead: Washington University School of Medicine
Collaborator Sponsor
Source: ClinicalTrials.gov ID: NCT00869817