Start: January 2009
End: July 2024
Enrollment: 700
This study will identify the biological changes that occur in the development of Alzheimer's disease to improve early diagnosis and to track progression of the disease. Researchers will collect biological information from adults who have parents a known inheritable, genetic mutation for Alzheimer's disease, specifically mutations in presenilin 1 (PSEN1), presenilin 2 (PSEN2), and amyloid precursor protein (APP) genes. Participants will undergo genetic testing, brain imaging, and provide blood and spinal fluid samples. Researchers will measure the amount of abnormal amyloid in the brain and spinal fluid, changes in brain size (e.g. shrinkage), and brain metabolism (energy processing). They will compare the changes that occur in participants with and without mild Alzheimer's symptoms, who may or may not have an Alzheimer's genetic mutation. All results will be stored in the Dominantly Inherited Alzheimer's Network (DIAN) Central Archive, an international database that allows qualified researchers to access and analyze the information. All information will be anonymized to ensure the privacy of the participants. Participants may choose to receive the results of their genetic test, and if so, will have access to genetic counseling at no cost.
Minimum Age: 18 Years
Maximum Age: N/A
Contact study personnel listed either under the general study contact or the location nearest you.
Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.
Florida | |
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Mayo Clinic Jacksonville
Jacksonville, FL 32224
Recruiting
Mary Imhansiemhonehi, MPH |
|
Indiana | |
Indiana University-Indiana Alzheimer Disease Center
Indianapolis, IN 46202
Recruiting
Jill Buck, RN |
|
Massachusetts | |
Brigham and Women's Hospital
Boston, MA 02115
Recruiting
Colleen Fitzpatrick, MS |
|
Missouri | |
Washington University in St. Louis School of Medicine
Saint Louis, MO 63108
Recruiting
Wendy Sigurdson, RN, MPH |
|
New York | |
Columbia University
New York, NY 10032
Recruiting
Naara Ramirez-Estevez |
|
Pennsylvania | |
University of Pittsburgh
Pittsburgh, PA 15260
Recruiting
Zana Ikonomovic, MD |
|
Rhode Island | |
Butler Hospital
Providence, RI 02906
Recruiting
Courtney Bodge, PhD |
Lead: Washington University School of Medicine
Collaborator Sponsor
Source: ClinicalTrials.gov ID: NCT00869817
An official website of the U.S. government, managed by the National Institutes on Aging at the National Institutes of Health