Start: December 2012
End: October 2027
Enrollment: 490
This ongoing study is testing the safety and effectiveness of several experimental drugs to slow the progression of cognitive impairment in people with an inherited Alzheimer's disease-causing gene mutation. Specifically, mutations in presenilin 1 (PSEN1), presenilin 2 (PSEN2), and amyloid precursor protein (APP) genes are associated with inherited Alzheimer's disease. All participants will be tested to determine if they have one of the mutations. Participants found to have one of the mutations will be randomly assigned to receive injections of one of the study drugs. Those participants who do not have a mutation will be randomly assigned to receive injections of either a study drug or a placebo. Injections will be given every four weeks for up to 208 weeks. Researchers will measure changes in cognition, blood and spinal fluid biomarkers, abnormal amyloid and tau protein in the brain, and brain glucose metabolism. Measurements will be done at the start of the study and then again at weeks 52, 104, 156, and 208. The study, called DIAN-TU, will test several different study drugs, starting with gantenerumab and solanezumab.
Minimum Age: 18 Years
Maximum Age: 80 Years
Contact study personnel listed either under the general study contact or the location nearest you.
Who Is the General Study Contact?
For more information about this study or study sites, visit the study website, call 1-844-342-6397, or email dianexr@wustl.edu.
Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.
Alabama | |
---|---|
University of Alabama in Birmingham
Birmingham, AL 35294
Recruiting
|
|
California | |
University of California San Diego Medical Center
La Jolla, CA 92037
Recruiting
|
|
USC Keck School of Medicine
Los Angeles, CA 90033
Not yet recruiting
|
|
Georgia | |
Emory University
Atlanta, GA 30329
Recruiting
|
|
Illinois | |
Advocate Lutheran General Hospital
Park Ridge, IL 60068
Recruiting
|
|
Indiana | |
Indiana University School of Medicine
Indianapolis, IN 46202
Recruiting
|
|
Missouri | |
Washington University in St. Louis
Saint Louis, MO 63110
Recruiting
|
|
Pennsylvania | |
University of Pittsburgh
Pittsburgh, PA 15213
Recruiting
|
|
Rhode Island | |
Butler Hospital
Providence, RI 02096
Recruiting
|
|
Texas | |
Kerwin Medical Center
Dallas, TX 75231
Not yet recruiting
|
|
Washington | |
University of Washington
Seattle, WA 98195
Recruiting
|
Lead: Washington University School of Medicine
Collaborator Sponsor
Source: ClinicalTrials.gov ID: NCT01760005