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Enhanced Mediterranean Diet for Alzheimer's Disease Prevention

Start: March 7, 2019
End: February 2023
Enrollment: 200

What Is This Study About?

This study investigates how the Mediterranean diet and low-fat eating patterns affect cognitive function and other measures, such as brain volume and blood pressure, in cognitively normal older adults. Participants will be randomly assigned to either a Mediterranean or low-fat diet for one year. The Mediterranean diet consists of fruits, vegetables, grains, dairy, olive oil, seafood, and nuts. Additionally, participants will be randomized to take either 2 grams of an omega-3 fatty acid supplement or placebo. During the study, participants will track the food they eat, be monitored by a registered dietitian, and engage in monthly food demonstrations and cooking classes. They will also pick up a bag of groceries weekly for six months from a local grocery store. After one year, people may continue in the study for up to two years for additional measurements.

Do I Qualify To Participate in This Study?

Minimum Age: 65 Years

Maximum Age: N/A

Must have:

  • Cognitively normal (Mini-Mental State Examination score greater than 25; AD8 score of 2 or less; no prior diagnosis of mild cognitive impairment, Alzheimer's disease or dementia; and not medically treated for cognitive impairment or dementia)
  • Speak English as a primary language
  • Live in the Kansas City metropolitan area
  • Body mass index of 20 to 40

Must NOT have:

  • Serious medical risk, such as type 1 diabetes, cancer, or recent cardiac event, including heart attack or angioplasty
  • Nut or fish allergy (does not include shellfish)
  • Specialized diet, such as vegan
  • Severe major depression or major psychiatric disorder that could interfere with study participation
  • Alcohol abuse (more than 3 drinks per day or total of 18 per week) or drug abuse
  • Do not have access to or independence over grocery shopping and meal preparation (for example, people living in a retirement community with reliance on dining facilities for meals)
  • Already consume a Mediterranean or low-fat diet
  • Prohibited medications: warfarin
 
Study Contact
Juleah Littrell

Need Help?

Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.

Where Is This Study Located?

Kansas
University of Kansas Medical Center
Kansas City, KS 66160
Recruiting
Juleah Littrell, MS, RD, LD

Who Sponsors This Study?

Lead: University of Kansas Medical Center

Collaborator Sponsor

  • National Institute on Aging (NIA)

Source: ClinicalTrials.gov ID: NCT03841539