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Enhanced Mediterranean Diet for Alzheimer's Disease Prevention

Start: March 7, 2019
End: February 2023
Enrollment: 200

What Is This Study About?

This study investigates how the Mediterranean diet and low-fat eating patterns affect cognitive function and other measures, such as brain volume and blood pressure, in cognitively normal older adults. Participants will be randomly assigned to either a Mediterranean or low-fat diet for one year. The Mediterranean diet consists of fruits, vegetables, grains, dairy, olive oil, seafood, and nuts. Additionally, participants will be randomized to take either 2 grams of an omega-3 fatty acid supplement or placebo. During the study, participants will track the food they eat, be monitored by a registered dietitian, and engage in monthly food demonstrations and cooking classes. They will also pick up a bag of groceries weekly for six months from a local grocery store. After one year, people may continue in the study for up to two years for additional measurements.

Do I Qualify To Participate in This Study?

Minimum Age: 65 Years

Maximum Age: N/A

Must have:

  • Cognitively normal (Mini-Mental State Examination score greater than 25; AD8 score of 2 or less; no prior diagnosis of mild cognitive impairment, Alzheimer's disease or dementia; and not medically treated for cognitive impairment or dementia)
  • Speak English as a primary language
  • Live in the Kansas City metropolitan area
  • Body mass index of 20 to 40

Must NOT have:

  • Serious medical risk, such as type 1 diabetes, cancer, or recent cardiac event, including heart attack or angioplasty
  • Nut or fish allergy (does not include shellfish)
  • Specialized diet, such as vegan
  • Severe major depression or major psychiatric disorder that could interfere with study participation
  • Alcohol abuse (more than 3 drinks per day or total of 18 per week) or drug abuse
  • Do not have access to or independence over grocery shopping and meal preparation (for example, people living in a retirement community with reliance on dining facilities for meals)
  • Already consume a Mediterranean or low-fat diet
  • Prohibited medications: warfarin

If I Qualify, Who Do I Contact?

Contact study personnel listed either under the general study contact or the location nearest you.

 
Study Contact
Juleah Littrell, MS, RD, LD

Need Help?

Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.

Where Is This Study Located?

Kansas
University of Kansas Medical Center
Kansas City, KS 66160
Recruiting
Juleah Littrell, MS, RD, LD

Who Sponsors This Study?

Lead: University of Kansas Medical Center

Collaborator Sponsor

  • National Institute on Aging (NIA)

Source: ClinicalTrials.gov ID: NCT03841539