Start: July 16, 2020
End: October 2025
Enrollment: 30
Growing evidence suggests that insulin affects normal memory processes and that abnormal insulin levels may contribute to cognitive and brain changes associated with Alzheimer's disease. The Study of Nasal Insulin to Fight Forgetfulness (SNIFF) will test devices that deliver insulin through the nose, and the effects of insulin on memory and insulin levels in the blood and cerebrospinal fluid. Participants will be randomized to receive either 20 or 40 units of insulin, delivered through the nose, over two study visits. Researchers will measure changes in memory, biomarkers for Alzheimer's disease, and insulin levels in the blood and cerebrospinal fluid.
Minimum Age: 55 Years
Maximum Age: 85 Years
Contact study personnel listed either under the general study contact or the location nearest you.
Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.
Lead: Wake Forest University Health Sciences
Source: ClinicalTrials.gov ID: NCT04199767