Skip to main content
U.S. flag

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock (  ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Find more clinical trials

MRI-Guided Transcranial Magnetic Stimulation for MCI

Start: October 21, 2020
End: June 2025
Enrollment: 60

What Is This Study About?

Transcranial magnetic stimulation (TMS) is a noninvasive procedure that involves the use of magnetic fields to stimulate areas of the brain. This study will test different doses and applications of TMS in adults with  mild cognitive impairment (MCI), a precursor to Alzheimer's disease. Participants will first undergo two separate sessions in which they receive continuous or intermittent stimulation to determine the optimal protocol for them based on memory tasks. Participants will then undergo 30-minute stimulation sessions Monday through Friday for four weeks. They will also participate in several two- to three-hour testing sessions involving brain imaging, neuropsychological testing, memory tasks, and other assessments throughout the study.

Do I Qualify To Participate in This Study?

Minimum Age: 50 Years

Maximum Age: 80 Years

Must have:


  • Self- or informant-reported cognitive complaint
  • Preserved independence in daily activities
  • Absence of dementia
  • Mini-Mental State Examination (MMSE) score of 24 to 27, Montreal Cognitive Assessment (MoCA) score of 18 to 26, or Clinical Dementia Rating (CDR) Scale score of 0.5
  • Right-handed
  • English speaking
  • Able to attend daily weekday sessions for 4 weeks
  • Not enrolled in another interventional study within 6 months prior to study start

Must NOT have:

  • Inability to undergo transcranial magnetic stimulation or magnetic resonance imaging
  • Other neurological disorders, such as stroke, head injuries, or multiple sclerosis
  • Untreated depression
  • Current cancer treatment or other medical problems that might affect study or results
  • Clinical Dementia Rating (CDR) Scale score more than 1.0

If I Qualify, Who Do I Contact?

Contact study personnel listed either under the general study contact or the location nearest you.

Study Contact
Yu-Chin Chen, M.D.
Ying-hui Chou, Sc.D.

Need Help?

Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.

Where Is This Study Located?

Bioscience Research Laboratory
Tucson, AZ 85719
Lisbeth Haaheim

Who Sponsors This Study?

Lead: University of Arizona

Source: ID: NCT03962959

An official website of the U.S. government, managed by the National Institute on Aging at the National Institutes of Health