Start:
July 12, 2017
End:
August 2022
Enrollment:
48
Nicotinamide, or niacinamide, is a form of vitamin B3 that researchers are exploring for its possible use in reducing tau, a protein that accumulates in tangles in the brain's of people with Alzheimer's disease. This Phase 2 trial will test the effects of a high dose of nicotinamide in adults with mild cognitive impairment (MCI) or mild Alzheimer's disease. Participants will be randomly assigned to take two tablets daily of either nicotinamide or a placebo pill for 48 weeks. Researchers will measure changes in tau levels in cerebrospinal fluid. The study includes four study visits. An additional 12-month treatment and follow-up period is possible, contingent on initial findings.
Minimum Age: 50 Years
Maximum Age: N/A
Contact study personnel listed either under the general study contact or the location nearest you.
Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.
Lead: University of California, Irvine
Source: ClinicalTrials.gov ID: NCT03061474
An official website of the U.S. government, managed by the National Institute on Aging at the National Institutes of Health