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Pomegranate Juice and Memory

Start: January 2014
End: May 2018
Enrollment: 212

What Is This Study About?

This study will examine whether drinking pomegranate juice daily for 1 year will benefit cognitive abilities in middle-aged and older adults without dementia. Researchers predict that participants who drink pomegranate juice will show better cognitive performance than those who drink a placebo.

Do I Qualify To Participate in This Study?

Minimum Age: 50 Years

Maximum Age: 75 Years

Must have:

  • Normal cognition or mild cognitive impairment
  • Adequate seeing and hearing ability to allow neuropsychological testing
  • Screening laboratory tests and EKG without significant abnormalities that might interfere with the study; if tests show abnormalities, subject must obtain written clearance from primary care physician

Must NOT have:

  • Diagnosis of probable Alzheimer's disease or any other dementia
  • Evidence of other neurological or physical illness that can produce cognitive deterioration
  • History of stroke, transient ischemic attack, carotid bruits, or lacunes seen on MRI scan
  • Contraindication to MRI, including claustrophobia, metal in body, surgery within past 60 days, certain implants, or previous abnormal MRI results
  • Evidence of Parkinson's disease
  • History of myocardial infarction within the past year or unstable cardiac disease
  • Uncontrolled hypertension (systolic blood pressure > 170 mm Hg or diastolic blood pressure > 100 mm Hg)
  • History of significant liver disease, clinically significant pulmonary disease, or diabetes
  • Current diagnosis of any major psychiatric disorder
  • Current diagnosis or history of alcoholism or substance addiction
  • Pregnancy
  • Regular use of any medication that may affect cognitive functioning, including: centrally active beta-blockers, narcotics, clonidine, anti-Parkinsonian medications, antipsychotics, systemic corticosteroids, medications with significant cholinergic or anticholinergic effects, anticonvulsants, or warfarin
  • Occasional use of anxiety or sleeping medications known to cause cognitive dulling will be allowed but discouraged: chloral hydrate; non-benzodiazepine hypnotics such as Ambien (zolpidem) or Lunesta (eszopiclone); benzodiazepines such as Ativan (lorazepam), Xanax (alprazolam), Klonopin (clonazepam), and Restoril (temazepam)
  • Other prohibited medications: amitriptyline, amiodarone, desipramine, fenofibrate, flecainide, fluconazole, fluoxetine, fluvastatin, fluvoxamine, isoniazid, lovastatin, ondansetron, phenylbutazone, probenecid, sertraline, sulfamethoxazole, sulfaphenazole, teniposide, voriconazole, and zafirlukast; supplements such as ginkgo biloba or anything containing pomegranate or pomegranate juice

If I Qualify, Who Do I Contact?

Contact study personnel listed either under the general study contact or the location nearest you.


Need Help?

Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.

Where Is This Study Located?

Who Sponsors This Study?

Lead: University of California, Los Angeles

Collaborator Sponsor

  • POM Wonderful LLC

Source: ID: NCT02093130