Skip to main content
U.S. flag

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock (  ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Find more clinical trials

Sensory Stimulation to Improve Brain Function (Overture Study)

Start: April 24, 2018
End: September 2021
Enrollment: 60

What Is This Study About?

The Overture Study is a Phase I/II clinical trial to study safety, adherence rates, and efficacy of the Active GammaSense Stimulation System in older adults with mild cognitive impairment (MCI) and Alzheimer's disease. The device provides noninvasive auditory and visual sensory stimulation to the brain.

Do I Qualify To Participate in This Study?

Minimum Age: 55 Years

Maximum Age: N/A

Must have:

  • Mini-Mental State Examination Score of 14 to 26
  • Early Alzheimers disease, Alzheimers disease, or MCI due to Alzheimers disease
  • Participation of a caregiver

Must NOT have:

  • Profound hearing or visual impairment
  • Seizure disorder
  • Use of memantine (Namenda or Namzaric)
  • Implantable devices that are not compatible with magnetic resonance imaging

If I Qualify, Who Do I Contact?

Contact study personnel listed either under the general study contact or the location nearest you.


Need Help?

Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.

Where Is This Study Located?

Who Sponsors This Study?

Lead: Cognito Therapeutics, Inc.

Source: ID: NCT03556280

An official website of the U.S. government, managed by the National Institutes on Aging at the National Institutes of Health