Sleep Intervention to Enhance Cognitive Status and Reduce Beta-Amyloid (SIESTA)
Start: August 27, 2019
End: January 2023
Enrollment: 200
What Is This Study About?
This study will investigate the effects of a sleep intervention on improving cognitive function in older adults with insomnia. The training is designed to improve sleep by addressing a person's sleep environment, schedules, behaviors, and thoughts. Participants will be randomly assigned to weekly one-hour personal training sessions or stretching and thinking activities for six weeks. Participants in the sleep training group will also maintain a sleep diary, and some will undergo brain imaging to examine the effects of training on reducing the accumulation of proteins associated with Alzheimer's disease. Researchers will measure changes in cognitive function.
Do I Qualify To Participate in This Study?
Minimum Age: 60 Years
Maximum Age: 85 Years
Must have:
- Difficulty falling asleep, maintaining sleep, or waking up too early at least 3 nights a week for the past 6 months
- Insomnia Severity Index score of 10 or greater
- Mini-Mental State Examination score of 25 or greater
- Dementia Screening Interview score of 2 or less
Must NOT have:
- Known untreated sleep disorder, such as sleep apnea or restless leg syndrome
- Currently taking benzodiazepines, nonbenzodiazepines, melatonin supplements, or agonists for insomnia
- Severe depression (Patient Health Questionnaire score of 15 or more) or suicidal ideation
- History of drug or alcohol abuse in past 2 years
- History of a nervous system disorder, such as stroke or Parkinson's disease
- Severe mental illness, such as schizophrenia or bipolar disorder
- History of a learning disability or attention-deficit/hyperactivity disorder
- Current or previous shift work
- Currently receiving treatment for sleep problems
- Unable to hear at a conversational level
- Failure of a near vision test
If I Qualify, Who Do I Contact?
Contact study personnel listed either under the general study contact or the location nearest you.
Need Help?
Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.
Where Is This Study Located?
| Kansas | |
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University of Kansas Medical Center- Sleep, Health and Wellness Laboratory
Kansas City, KS 66160
Recruiting
Eryen Nelson, MPH |
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Who Sponsors This Study?
Lead: University of Kansas Medical Center
Collaborator Sponsor
- National Institute on Aging (NIA)
- National Institutes of Health (NIH)
Source: ClinicalTrials.gov ID: NCT03954210