Start: August 2015
End: August 2023
This study will assess how the Alzheimer's-associated protein tau is made, transported, and cleared using a novel approach to measure tau with an essential amino acid called leucine, which is naturally available in many foods. Researchers are recruiting younger and older adults who are cognitively normal and older adults with Alzheimer's disease. Participants will either be given leucine through intravenous infusion (IV) or in a drink. The IV method will first be tested in a young control group. Meals will be provided by the research kitchen to control for the natural leucine found in people's diets. If IV infusion is not successful, the study will use a proven oral method of providing leucine. Participants will pick up food three times a week, along with a leucine supplement that they will mix and drink in Kool-Aid three times a day for 10 days. All participants will undergo five lumbar punctures in order for researchers to analyze tau in their cerebrospinal fluid.
Minimum Age: 18 Years
Maximum Age: N/A
Contact study personnel listed either under the general study contact or the location nearest you.
Washington University in Saint Louis
Saint Louis, MO 63110
Lead: Washington University School of Medicine
Source: ClinicalTrials.gov ID: NCT03938870