Therapeutic Diets in Alzheimer's Disease

What Is This Study About?

In this study researchers will investigate how the ketogenic and Therapeutic Lifestyle Changes diets affect cognition in adults with Alzheimer's disease. The ketogenic diet is a high-fat, low-carbohydrate diet and participants will also take daily supplements. The Therapeutic Lifestyle Changes diet is low in fat and cholesterol; high in fruits, vegetables, and whole grains; and moderate in protein. Participants will be randomly assigned to one of the two diets for three months and researchers will measure changes in cognitive performance, including memory and reaction times, using several assessments and tests.

Do I Qualify To Participate in This Study?

Must have:

• Diagnosis of Alzheimer's disease
• Clinical Dementia Rating global score of 0.5 or 1 (very mild or mild dementia)
• Agreed cooperation from an appropriate study partner
• Speaks English as primary language
• No medication changes in past 30 days

Must NOT have:

• Resides in a nursing home or dementia special care unit, or cannot control diet
• A potentially confounding serious medical risk (e.g., diabetes requiring insulin; cancer requiring chemotherapy or radiation within the past five years; or a recent heart attack, angioplasty, or other cardiac event)
• Participating in another clinical trial or using an investigational drug or therapy within 30 days of screening
• History of renal stones

If I Qualify, Who Do I Contact?

Contact study personnel listed either under the general study contact or the location nearest you.

 

Where Is This Study Located?

Kansas
Clinical and Translational Science Unit Fairway, KS 66205 Recruiting

Who Sponsors This Study?

Lead: University of Kansas Medical Center

Collaborator Sponsor

• National Institute on Aging (NIA)

Source: ClinicalTrials.gov ID: NCT03860792