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Find more clinical trials

Theta Burst Brain Stimulation To Improve Memory in Older Adults With Mild Cognitive Impairment

Start: January 26, 2021
End: June 2025
Enrollment: 70

What Is This Study About?

Theta burst transcranial magnetic stimulation (TBS) is a noninvasive approach to increase brain activity. This study will examine whether TBS improves memory in older adults with mild cognitive impairment. Participants will be randomly assigned to receive TBS or a sham treatment over 18 days. Researchers will assess changes in memory and use tests and brain scans to evaluate brain activity.

Do I Qualify To Participate in This Study?

Minimum Age: 55 Years

Maximum Age: 90 Years

Must have:

  • Good general health
  • Native English speaker with the ability to read, write, and speak English fluently
  • Adequate vision and hearing to complete neuropsychological testing
  • Diagnosis of mild cognitive impairment, with Mini-Mental Examination Score >24
  • Living independently
  • If taking psychotropic medication for the treatment of depression, anxiety, or psychosis, the dosage must be stable for at least one month before and during the study
  • Right-handed

Must NOT have:

  • Diagnosis of dementia
  • Major psychiatric or neurologic disorders
  • Abnormal electrocardiogram or laboratory test results that could interfere with the study
  • Alcohol or substance abuse within the past six months; nicotine or caffeine use is acceptable
  • History of stroke, traumatic brain injury with loss of consciousness, or other neurologic disorder (e.g., epilepsy, Huntington's disease, Parkinson's disease)
  • Previously received any kind of transcranial magnetic stimulation 
  • Head trauma, or health conditions or diseases that affect brain function
  • Uncontrolled high blood pressure or cardiovascular disease
  • Current enrollment in a memory-enhancement study or course
  • Previous abnormal MRI brain scan or any conditions that may make having an MRI unsafe (e.g., metal shrapnel, heart pacemaker, severe claustrophobia, surgery within the past 60 days)
  • Current use of anticholinergic medication; sedating antihistamine; any drug that has significant anticholinergic or antihistaminic side effects; use of benzodiazepines may be considered

If I Qualify, Who Do I Contact?

Contact study personnel listed either under the general study contact or the location nearest you.

Study Contact
Sonja Hiller

Need Help?

Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.

Where Is This Study Located?

University of California Los Angeles
Los Angeles, CA 90024
Sonja Hiller

Who Sponsors This Study?

Lead: University of California, Los Angeles

Collaborator Sponsor

  • National Institute on Aging (NIA)

Source: ID: NCT04558164

An official website of the U.S. government, managed by the National Institute on Aging at the National Institutes of Health