Start: January 26, 2021
End: June 2025
What Is This Study About?
Theta burst transcranial magnetic stimulation (TBS) is a noninvasive approach to increase brain activity. This study will examine whether TBS improves memory in older adults with mild cognitive impairment. Participants will be randomly assigned to receive TBS or a sham treatment over 18 days. Researchers will assess changes in memory and use tests and brain scans to evaluate brain activity.
Do I Qualify To Participate in This Study?
- Good general health
- Native English speaker with the ability to read, write, and speak English fluently
- Adequate vision and hearing to complete neuropsychological testing
- Diagnosis of mild cognitive impairment, with Mini-Mental Examination Score >24
- Living independently
- If taking psychotropic medication for the treatment of depression, anxiety, or psychosis, the dosage must be stable for at least one month before and during the study
Must NOT have:
- Diagnosis of dementia
- Major psychiatric or neurologic disorders
- Abnormal electrocardiogram or laboratory test results that could interfere with the study
- Alcohol or substance abuse within the past six months; nicotine or caffeine use is acceptable
- History of stroke, traumatic brain injury with loss of consciousness, or other neurologic disorder (e.g., epilepsy, Huntington's disease, Parkinson's disease)
- Previously received any kind of transcranial magnetic stimulation
- Head trauma, or health conditions or diseases that affect brain function
- Uncontrolled high blood pressure or cardiovascular disease
- Current enrollment in a memory-enhancement study or course
- Previous abnormal MRI brain scan or any conditions that may make having an MRI unsafe (e.g., metal shrapnel, heart pacemaker, severe claustrophobia, surgery within the past 60 days)
- Current use of anticholinergic medication; sedating antihistamine; any drug that has significant anticholinergic or antihistaminic side effects; use of benzodiazepines may be considered
If I Qualify, Who Do I Contact?
Contact study personnel listed either under the general study contact or the location nearest you.
Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.
Where Is This Study Located?
Lead: University of California, Los Angeles
National Institute on Aging (NIA)
Source: ClinicalTrials.gov ID: NCT04558164