Skip to main content
U.S. flag

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock (  ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Find more clinical trials

Training to Reduce Care-Resistant Behaviors in Alzheimer's and TBI (NeuroNS-Care)

Start: February 1, 2017
End: August 2021
Enrollment: 150

What Is This Study About?

This study will test the effectiveness of an Internet-based distance-learning program in reducing care-resistant behaviors, including agitation, aggression, and irritability, in people with Alzheimer's disease or traumatic brain injury (TBI).

Do I Qualify To Participate in This Study?

Minimum Age: 18 Years

Maximum Age: N/A

Must have:

  • Possible or probable Alzheimer's disease (of all severity stages) or moderate to severe TBI at least 6 months prior to study enrollment
  • Family caregiver (unpaid) who provides support or supervision for at least one instrumental activity of daily living for the affected person, with direct contact averaging 5 of every 7 days, and 21 hours weekly
  • Caregiver report of agitation/aggression, disinhibition, or irritability on the Neuropsychiatric Inventory that is triggered by resistance to care-related activities, such as bathing, taking medications, or attending healthcare appointments
  • Generally healthy and able to walk (assistance devices such as a walker or cane are allowed)
  • Vision and hearing sufficient to complete testing procedures (hearing aid allowed)
  • Cognitive function and spoken/written English sufficient to complete neuropsychological testing
  • May be on stable doses of psychoactive agents for at least 30 days
  • Access to high-speed/broadband Internet service through home computer capable of operating conference software

Must NOT have:

  • Evidence of other psychiatric/neurological disorders that could be the primary source of cognitive impairment, such as stroke, Parkinson's disease, schizophrenia, bipolar or unipolar depression, and seizure disorder
  • Psychotic features, such as delusions or hallucinations, that are not adequately treated or not on stable medical therapy for at least 30 days
  • Alcoholism or drug misuse within past 2 years
  • Any condition that would make the participant or caregiver unsuitable for the study

If I Qualify, Who Do I Contact?

Contact study personnel listed either under the general study contact or the location nearest you.


Need Help?

Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.

Where Is This Study Located?

Who Sponsors This Study?

Lead: University of Alabama at Birmingham

Source: ID: NCT03734289

An official website of the U.S. government, managed by the National Institutes on Aging at the National Institutes of Health