Start: July 1, 2021
End: June 30, 2026
This study will examine whether veterans with a history of traumatic brain injury (TBI) have an elevated risk of developing dementia. Researchers will recruit veterans who are either healthy, have a history of TBI, or have mild cognitive impairment (MCI). In three study sessions, participants will undergo a neuropsychological assessment, MRI brain scans, provide blood and spinal fluid samples, and complete memory tests. Researchers will also measure participant brain activity as they complete a computer-based memory test. Over five years, researchers will continue to measure changes in memory, brain activity, and markers of neurodegeneration. The blood samples will be used for genetic testing for the APOE gene, associated with the risk of developing Alzheimer's disease.
Minimum Age: 30 Years
Maximum Age: 90 Years
Participants With Mild TBI:
Participants With Moderate TBI:
Participants With MCI:
Contact study personnel listed either under the general study contact or the location nearest you.
Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.
VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
Boston, MA 02130
RecruitingKristina Morreale, BA
Lead: VA Office of Research and Development
Source: ClinicalTrials.gov ID: NCT04124029