Light Exposure to Improve Cognition, Sleep, and Metabolism

What Is This Study About?

This study will evaluate the long-term effects of a treatment using light on cognition, sleep, and metabolism in people with mild cognitive impairment (MCI), mild Alzheimer's disease, or a related dementia. Participants will be randomly assigned to receive either a tailored light intervention or a placebo treatment at home for six months. The intervention will provide daily stimulation with bluish-white (experimental) or yellow-white (control) light sources that are tuned to the sensitivity of the circadian system, which controls the human sleep-wake cycle. Researchers will measure if the intervention can reduce sleep disturbances, inflammation, insulin sensitivity, and improve glucose metabolism and cognition.

Do I Qualify To Participate in This Study?

Must have:

• MCI, mild Alzheimer's disease, or a related dementia with:
  • MMSE score of >19 or Clinical Dementia Rating of 0.5 or 1
• Sleep problems, including waking often or having trouble staying asleep through the night
• Live at home

Must NOT have:

• Blindness
• Insulin-dependent diabetes
• Macular degeneration
• Severe sleep apnea

If I Qualify, Who Do I Contact?

Contact study personnel listed either under the general study contact or the location nearest you.

 

Where Is This Study Located?

New Jersey
Rutgers University New Brunswick, NJ 08854 Recruiting Christoph Buettner, MD cb1116@rwjms.rutgers.edu
New York
Icahn School of Medicine at Mount Sinai New York, NY 10029 Recruiting Christoph Buettner, MD, PhD 212-241-3425 christoph.buettner@mssm.edu

Who Sponsors This Study?

Lead: Rensselaer Polytechnic Institute

Collaborator Sponsor

• Icahn School of Medicine at Mount Sinai

Source: ClinicalTrials.gov ID: NCT03933696