Longitudinal Study of APOE and the Risk of Alzheimer's Disease

What Is This Study About?

Different variants of the apolipoprotein E (APOE) gene have been associated with different levels of risk for developing Alzheimer's disease. This long-term study will gather data in cognitively normal older adults and compare cognitive, behavioral, and physical changes across different APOE variants, or genotypes. Once a year, participants will provide blood samples for clinical lab analysis and genetic testing. Every two years, participants will provide cerebrospinal fluid samples, undergo positron emission topography (PET) and MRI brain scans, and complete a series of tests to assess cognitive function, risk factors, and other measures.

Do I Qualify To Participate in This Study?

Must have:

• No cognitive impairment
• Good general health

Must NOT have:

• Any significant health issues or medical diseases that could interfere with study participation
• Pregnancy or breastfeeding
• Females of childbearing potential must have a negative pregnancy test or be two years postmenopausal or surgically sterile
• Any condition or device that would make getting an MRI unsafe (e.g., pacemaker, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects in the eyes, skin, or body)
• Any medical or surgical history that would make getting a lumbar puncture unsafe (e.g., taking blood thinners or history of lumbar spinal surgery)

If I Qualify, Who Do I Contact?

Contact study personnel listed either under the general study contact or the location nearest you.

 

Where Is This Study Located?

Arizona
Banner Alzheimer's Institute Phoenix, AZ 85006 Recruiting Katie DeMarco 602-839-2033 Kathryn.DeMarco@bannerhealth.com

Who Sponsors This Study?

Lead: Banner Health

Collaborator Sponsor

• Mayo Clinic

Source: ClinicalTrials.gov ID: NCT04994847