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La información sobre este estudio está en inglés.

Si necesita ayuda en español, comuníquese con el Centro de Educación y Referencias sobre la Enfermedad de Alzheimer y las Demencias Relacionadas (ADEAR, por sus siglas en inglés) por teléfono al 800-438-4380 o envíe un correo electrónico. También puede llamar o enviar un correo electrónico al contacto del estudio (en inglés) para obtener información adicional.

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Longitudinal Study of APOE and the Risk of Alzheimer's Disease

Start: May 1, 2021
End: June 30, 2026
Enrollment: 300

What Is This Study About?

Different variants of the apolipoprotein E (APOE) gene have been associated with different levels of risk for developing Alzheimer's disease. This long-term study will gather data in cognitively normal older adults and compare cognitive, behavioral, and physical changes across different APOE variants, or genotypes. Once a year, participants will provide blood samples for clinical lab analysis and genetic testing. Every two years, participants will provide cerebrospinal fluid samples, undergo positron emission topography (PET) and MRI brain scans, and complete a series of tests to assess cognitive function, risk factors, and other measures.

Do I Qualify To Participate in This Study?

Minimum Age: 50 Years

Maximum Age: 90 Years

Must have:

  • No cognitive impairment
  • Good general health

Must NOT have:

  • Any significant health issues or medical diseases that could interfere with study participation
  • Pregnancy or breastfeeding
  • Females of childbearing potential must have a negative pregnancy test or be two years postmenopausal or surgically sterile
  • Any condition or device that would make getting an MRI unsafe (e.g., pacemaker, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects in the eyes, skin, or body)
  • Any medical or surgical history that would make getting a lumbar puncture unsafe (e.g., taking blood thinners or history of lumbar spinal surgery)

If I Qualify, Who Do I Contact?

Contact study personnel listed either under the general study contact or the location nearest you.

Study Contact
Jennifer Craig-Muller

Need Help?

Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.

Where Is This Study Located?

Banner Alzheimer's Institute
Phoenix, AZ 85006
Katie DeMarco

Who Sponsors This Study?

Lead: Banner Health

Collaborator Sponsor

  • Mayo Clinic

Source: ID: NCT04994847