Start: July 2014
End: July 2016
What Is This Study About?
This study will examine the effects of taking a dietary supplement, magnesium L-threonate (brand name, Magtein), in people with mild to moderate dementia and a magnesium deficiency to see if it will improve memory and/or magnesium deficiency.
Do I Qualify To Participate in This Study?
- Mini-Mental State Examination score of 16-24
- Adequate seeing and hearing ability to allow neuropsychological testing
- More than 12 years of educational achievement or a General Education Development certificate
- Women must be surgically sterile, postmenopausal, or use an acceptable method of birth control
Must NOT have:
- Active heart disease
- Uncontrolled high blood pressure (≥ 140/90 mmHg)
- Renal or hepatic impairment/disease
- Type I diabetes
- Unstable thyroid disease
- Psychiatric disorder requiring hospitalization in the past year
- Drug or alcohol abuse in the past 12 months
- Immune disorder such as HIV/AIDS
- Transient ischemic attacks, carotid bruits, or verified lacunes
- Significant pulmonary disease
- Contraindication for PET scan, including a stroke or heart attack in the past 6 months or inability to lie down for 1 hour
- History of cancer (except localized skin cancer without metastases or in situ cervical cancer) within 5 years prior to screening
- Prohibited medications: medications known to interact with magnesium; antibiotics; vitamins, minerals or dietary/herbal supplements other than the study product until after study completion
- On an unstable dose of medication (defined as fewer than 90 days at the same dose)
- Allergy or sensitivity to any ingredient in the test product
- Pregnant , lactating, or planning to become pregnant during the study period
- Participation in another research study within 30 days prior to the screening visit
If I Qualify, Who Do I Contact?
Contact study personnel listed either under the general study contact or the location nearest you.
Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.
Where Is This Study Located?
Lead: Stanford University
Source: ClinicalTrials.gov ID: NCT02210286