Magnesium L-Threonate to Enhance Learning and Memory in People with Dementia

What Is This Study About?

This study will examine the effects of taking a dietary supplement, magnesium L-threonate (brand name, Magtein), in people with mild to moderate dementia and a magnesium deficiency to see if it will improve memory and/or magnesium deficiency.

Do I Qualify To Participate in This Study?

Must have:

• Mini-Mental State Examination score of 16-24
• Adequate seeing and hearing ability to allow neuropsychological testing
• More than 12 years of educational achievement or a General Education Development certificate
• Women must be surgically sterile, postmenopausal, or use an acceptable method of birth control

Must NOT have:

• Active heart disease
• Uncontrolled high blood pressure (≥ 140/90 mmHg)
• Renal or hepatic impairment/disease
• Type I diabetes
• Unstable thyroid disease
• Psychiatric disorder requiring hospitalization in the past year
• Drug or alcohol abuse in the past 12 months
• Immune disorder such as HIV/AIDS
• Transient ischemic attacks, carotid bruits, or verified lacunes
• Significant pulmonary disease
• Contraindication for PET scan, including a stroke or heart attack in the past 6 months or inability to lie down for 1 hour
• History of cancer (except localized skin cancer without metastases or in situ cervical cancer) within 5 years prior to screening
• Prohibited medications: medications known to interact with magnesium; antibiotics;  vitamins, minerals or dietary/herbal supplements other than the study product until after study completion
• On an unstable dose of medication (defined as fewer than 90 days at the same dose)
• Allergy or sensitivity to any ingredient in the test product
• Pregnant , lactating, or planning to become pregnant during the study period
• Participation in another research study within 30 days prior to the screening visit

If I Qualify, Who Do I Contact?

Contact study personnel listed either under the general study contact or the location nearest you.

 

Where Is This Study Located?

Who Sponsors This Study?

Lead: Stanford University

Collaborator Sponsor

• Magceutics Inc.

Source: ClinicalTrials.gov ID: NCT02210286