MRI-Guided Transcranial Magnetic Stimulation for MCI

What Is This Study About?

Transcranial magnetic stimulation (TMS) is a noninvasive procedure that involves the use of magnetic fields to stimulate areas of the brain. This study will test different doses and applications of TMS in adults with and without mild cognitive impairment (MCI), a precursor to Alzheimer's disease. Participants will first undergo two separate sessions in which they receive continuous or intermittent stimulation to determine the optimal protocol for them based on memory tasks. Participants will then undergo 30-minute stimulation sessions Monday through Friday for four weeks. They will also participate in several two- to three-hour testing sessions involving brain imaging, neuropsychological testing, memory tasks, and other assessments throughout the study.

Do I Qualify To Participate in This Study?

Must have:

Participants with MCI

• Self- or informant-reported cognitive complaint
• Preserved independence in daily activities
• Absence of dementia
• Mini-Mental State Examination (MMSE) score of 24 to 27, Montreal Cognitive Assessment (MoCA) score of 18 to 26, or Clinical Dementia Rating (CDR) Scale score of 0.5

Cognitively Normal Participants

• No cognitive impairment (MMSE score of 27 or more, MoCA score of 26 or higher, and CDR scale score of 0)

All Participants

• Right-handed
• English speaking
• Able to attend daily weekday sessions for 4 weeks
• Not enrolled in another interventional study within 6 months prior to study start

Must NOT have:

• Inability to undergo transcranial magnetic stimulation or magnetic resonance imaging
• Other neurological disorders, such as stroke, head injuries, or multiple sclerosis
• Untreated depression
• Current cancer treatment or other medical problems that might affect study or results

If I Qualify, Who Do I Contact?

Contact study personnel listed either under the general study contact or the location nearest you.

 

Where Is This Study Located?

Arizona
Bioscience Research Laboratory Tucson, AZ 85719 Recruiting Lisbeth Haaheim tms-lab@list.arizona.edu

Who Sponsors This Study?

Lead: University of Arizona

Source: ClinicalTrials.gov ID: NCT03962959