Tau PET Imaging and Cognition

What Is This Study About?

Tau is a protein that accumulates abnormally in the brains of people with Alzheimer's disease and other dementias. This study will use the new radioactive tracer 18F-MK-6240 in positron emission tomography (PET) scanning to detect tau pathology in older adults who are cognitively healthy and mildly cognitively impaired. Researchers will examine the interactions between tau levels and performance on cognitive tasks, neural activation patterns using functional MRI brain scans, and other cognitive and behavioral measures. The study also aims to examine how the presence of tau may contribute to the risk of subsequent cognitive decline, neurodegeneration, and dementia.

Do I Qualify To Participate in This Study?

Must have:

• Participation in amyloid PET scanning study
• Reside near Columbia University Medical Center
• Willing and able to participate

Must NOT have:

• Inability to undergo PET, such as metallic implants, pacemaker, claustrophobia, or difficulty lying flat for one hour
• Pregnant or lactating
• Current, past, or anticipated exposure to radiation
• Significant active physical illness

If I Qualify, Who Do I Contact?

Contact study personnel listed either under the general study contact or the location nearest you.

 

Where Is This Study Located?

New York
Columbia University Medical Center New York, NY 10032 Recruiting Ashley Mensing, BS 212-305-6314 ao2454@cumc.columbia.edu

Who Sponsors This Study?

Lead: Yaakov Stern

Collaborator Sponsor

• National Institute on Aging (NIA)

Source: ClinicalTrials.gov ID: NCT03372317